A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis
Published 4 Feb 10
In this 96-week, placebo-controlled trial, oral cladribine reduced relapse rates and lowered the risk of sustained disability in patients with relapsing-remitting multiple sclerosis. Patients who were treated with cladribine had large reductions in lymphocyte counts and more infections, including herpes zoster and one death from reactivation of tuberculosis. A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
Published 4 Feb 10
In this 24-month, randomized trial involving patients with relapsing-remitting multiple sclerosis, oral fingolimod reduced the rates of relapse and disability progression, as compared with placebo. Adverse events reported in patients treated with fingolimod included bradycardia, atrioventricular conduction block, macular edema, elevations in liver-enzyme levels, and mild hypertension. A Wii Fracture
Published 4 Feb 10
To the Editor: In 1990, Brasington described "Nintendinitis"1 in a patient with pain over the extensor tendon of her thumb ... Accuracy of Financial Disclosures Reported by Physicians
Published 4 Feb 10
To the Editor: Okike et al. (Oct. 8 issue)1 found that the rate of conflict-of-interest disclosure reported by physicians who ... Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2
Published 4 Feb 10
Suppressive therapy for herpes simplex virus 2 (HSV-2) has also been shown to reduce the levels of human immunodeficiency virus type 1 (HIV-1). However, in this placebo-controlled trial involving 3408 African couples who were discordant in serologic status for these two viruses, daily treatment with acyclovir did not reduce the frequency of HIV-1 transmission, despite a reduction in HIV-1 RNA levels and a 73% reduction in the occurrence of HSV-2-positive genital ulcers. |
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Old tobacco smoke a killer - report
Published 9 Feb 10
Old tobacco smoke does more than simply make a room smell stale - it can leave cancer-causing toxins behind, Reuters reported today.Researchers in the US found cancer-causing agents called tobacco-specific nitrosamines stick to... Heart Foundation launches appeal
Published 9 Feb 10
The Heart Foundation has launched its annual appeal, this year focusing on the impact of heart disease and strokes on the families of victims.The foundation says cardiovascular disease is the single biggest killer of men and women... Regular drink of beer helps strengthen bones, says study
Published 9 Feb 10
It may not be uppermost in the minds of pub goers eager to slake their thirst, but could aid negotiations on the domestic front.A regular tipple, it turns out, helps strengthen the bones and prevent fractures in old age - so long... Safer Down syndrome tests now available
Published 9 Feb 10
Health services are this week starting an expanded, safer screening programme to detect Down syndrome during pregnancy, after serious flaws were detected in the old system.All women who see a midwife or doctor in early pregnancy... The secret of youth: maybe it's all in your genes
Published 9 Feb 10
A genetic test for how quickly a person will age over the course of a lifetime may soon be possible, following a study that has for the first time identified DNA variations in the population that can be linked with biological ageing.Scientists... |